The LINUS distribution is a suite of programs for exploring conformational ensembles of peptides and proteins.
The core of LINUS is a torsion angle Monte Carlo simulation application that allows a restrained Monte Carlo move set with a simple atomic interaction energy acceptance criterion.
You may download the complete distribution as a gzipped tar archive by clicking on the link to the left.
The distribution contains a copy of the User Manual in html format.
If you would just like to peruse the User Manual click on the Documentation link to the left.
LINUS is written entirely in Python although some routines are also provided as C code.
The C routines will be called if they are compiled but they are not necessary.
References describing the use of LINUS are given in the reference list included with the distribution.
In addition, there will be an article forthcoming in Methods and Enzymology.
If you would like a manuscript version of that article please contact George Rose by email firstname.lastname@example.org.
LINUS was ported to Python with the goal of making a set of modules that would be useful for computational experimentation by a knowledgable user.
It is not distributed as a black box program with set protocols.
We find these modules very useful for answering "what if" questions about protein conformational diversity and we hope that the suite will be useful to others.
Please consider this distribution of LINUS as a suite of tools for your own implementation, modification and exploration.
This distribution comes with a caveat.
Our small lab is not able to respond adequately to requests for assistance, and therefore we have done our best to provide documentation.
We hope you will find this documentation to be sufficiently useful.
Copyright (C) 2002 Raj Srinivasan, Patrick Fleming, George Rose
This program is free software; you can redistribute it and/or
modify it under the terms of the GNU General Public License
as published by the Free Software Foundation; either version 2
of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU General Public License for more details.
You should have received a copy of the GNU General Public License
along with this program; if not, write to the Free Software
Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA.